Natural Antioxidant—Great for Liver Health

Milk Thistle References

  1. Cultivation of milk thistle (Silybum marianum L. Gaertn.), a medicinal weed. Karkanis, Anestis, Bilalis, Dimitrios and Efthimiadou, Aspasia. [ed.] D.T. Ray, M.J. Pascual-Villalobos and M.N. Belgacem. 1, Tucson; Murcia; St. Martin d'Hères: Elsevier B.V., July 2011, Industrial Crops and Products, Vol. 34, pp. 825-830. DOI: 10.1016/j.indcrop.2011.03.027; http://www.sciencedirect.com/science/article/pii/S092666901100104X. ISSN: 0926-6690.
  2. Brenneman, William L. 50 Wild Plants Everyone Should Know. Bloomington: AuthorHouse, 2010. ISBN-13: 978-1-4520-4637-2.
  3. Khan, Ikhlas A. and Abourashed, Ehab A. Leung's Encyclopedia of Common Natural Ingredients: Used in Food, Drugs and Cosmetics. 3. Hoboken: John Wiley & Sons, Inc., 2010. ISBN: 978-0-471-46743-4.
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  5. Quattrocchi, Umberto. CRC World Dictionary of Medicinal and Poisonous Plants: Common Names, Scientific Names, Eponyms, Synonyms, and Etymology. Boca Raton: CRC Press: Taylor & Francis Group, 2012. ISBN-13: 978-1-4822-5064-0.
  6. Bailey, Liberty Hyde and Miller, Wilhelm. Cyclopedia of American Horticulture, Comprising Suggestions for Cultivation of Horticultural Plants, Descriptions of the Species of Fruits, Vegetables, Flowers and Ornamental Plants Sold in the United States and Canada, Together with Geographical. New York: The Macmillan Company, 1904. Vol. 4.
  7. Parsons, W.T. and Cuthbertson, E.G. Noxious Weeds of Australia. 2nd. Collingwood: Csiro Publishing, 2001. ISBN: 0-643-06514-8.
  8. Philp, Robert Kemp. The Family Save-All, a System of Secondary Cookery. 2nd. London: W. Kent & Co., 1861.
  9. Memorial Sloan Kettering Cancer Center. Milk Thistle. Integrative Medicine: About Herbs, Botanicals & Other Products. [Online] September 3, 2014. [Cited: February 20, 2017.] https://www.mskcc.org/cancer-care/integrative-medicine/herbs/milk-thistle.
  10. Burbank, Luther. How Plants Are Trained to Work for Man: Gardening. New York: P.F. Collier & Son Company, 1921. Vol. V.
  11. Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. Ferenci, P., et al., et al. [ed.] Dame Sheila Sherlock. 1, London: Elsevier Inc.: European Association for the Study of the Liver, July 1989, Journal of Hepatology, Vol. 9, pp. 105-113. DOI: 10.1016/0168-8278(89)90083-4; http://www.journal-of-hepatology.eu/article/0168-8278(89)90083-4/abstract. ISSN: 0168-8278.
  12. Silymarin, the Antioxidant Component of Silybum marianum, Prevents Sepsis-Induced Acute Lung and Brain Injury. Toklu, Hale Z., et al., et al. [ed.] David W. McFadden and Wiley W. Souba. 2, Burlington; Columbus: Elsevier B.V., April 2008, Journal of Surgical Research, Vol. 145, pp. 214-222. DOI: 10.1016/j.jss.2007.03.072; http://www.journalofsurgicalresearch.com/article/S0022-4804(07)00237-5/abstract. ISSN: 0022-4804.
  13. An Updated Systematic Review with Meta-Analysis for the Clinical Evidence of Silymarin. Saller, Reinhard, et al., et al. [ed.] Harald Walach. 1, Poznan: S. Karger AG, Basel, February 2008, Complementary Medicine Research, Vol. 15, pp. 9-20. DOI: 10.1159/000113648; http://www.karger.com/Article/Abstract/113648. ISSN: 2504-2092.
  14. The effects of silymarin on experimental phalloidine poisoning. Desplaces, A., et al., et al. 1, s.l.: Georg Thieme Verlag KG, January 1975, Arzneimittelforschung, Vol. 25, pp. 89-96. ISSN: 0004-4172.
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  16. Characterization of chitosan-nanoclay bionanocomposite active films containing milk thistle extract. Ghelejlu, Sara Beigzadeh, Esmaiili, Mohsen and Almasi, Hadi. [ed.] A. Dong and J.F. Kennedy. Greeley; Bromsgrove: Elsevier B.V., May 2016, International Journal of Biological Macromolecules, Vol. 86, pp. 613-621. DOI: 10.1016/j.ijbiomac.2016.02.012; http://www.sciencedirect.com/science/article/pii/S0141813016301416. ISSN: 0141-8130.
  17. Chitin and chitosan: Properties and applications. Rinaudo, Marguerite. [ed.] G.C. Berry and K. Matyjaszewski. 7, Pittsburgh: Elsevier Ltd., July 2006, Progress in Polymer Science, Vol. 31, pp. 603-632. DOI: 10.1016/j.progpolymsci.2006.06.001; http://www.sciencedirect.com/science/article/pii/S0079670006000530. ISSN: 0079-6700.
  18. Silybum marianum extract as a natural source inhibitor for 304 stainless steel corrosion in 1.0 M HCl. Soltani, N., et al., et al. [ed.] Bok Ryul Yoo. 5, Seoul: Elsevier B.V., September 25, 2014, Journal of Industrial and Engineering Chemistry, Vol. 20, pp. 3217-3227. DOI: 10.1016/j.jiec.2013.12.002; http://www.sciencedirect.com/science/article/pii/S1226086X13006333. ISSN: 1226-086X.
  19. Biodiesel production from non-edible Silybum marianum oil using heterogeneous solid base catalyst under ultrasonication. Takase, Mohammed, et al., et al. [ed.] Timothy J. Mason. 5, Coventry: Elsevier B.V., September 2014, Ultrasonics Sonochemistry, Vol. 21, pp. 1752-1762. DOI: 10.1016/j.ultsonch.2014.04.003; http://www.sciencedirect.com/science/article/pii/S135041771400128X. ISSN: 1350-4177.
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  21. Phytotherapeutic properties of milk thistle seeds: An overview. Bhattacharya, Sanjib. [ed.] Eric Jones. Columbia: Elsevier, July 26, 2011, Journal of Advanced Pharmacy Education & Research, Vol. 1, pp. 69-79. ISSN: 2249-3379.
  22. Silibinin: A Thorny Therapeutic for EGF-R Expressing Tumors?. Hannay, Jonathan A.F. and Yu, Dihua. [ed.] Wafik S. El-Deiry. 5, Philadelphia: Landes Bioscience, September/October 2003, Cancer Biology & Therapy, Vol. 2, pp. 532-533. ISSN: 1538-4047.
  23. Ethnopharmacological survey of medicinal herbs in Israel, the Golan Heights and the West Bank region. Said, O., et al., et al. [ed.] Laurent Rivier and Jan G. Bruhn. 3, Lausanne: Elsevier Ireland Ltd., December 2002, Journal of Ethnopharmacology, Vol. 83, pp. 251-265. DOI: 10.1016/S0378-8741(02)00253-2; http://www.sciencedirect.com/science/article/pii/S0378874102002532. ISSN: 0378-8741.
  24. Traditional Chinese medicine and related active compounds: A review of their role on hepatitis B virus infection. Qi, Fanghua, et al., et al. [ed.] Kazuhisa Sekimizu. 6, Tokyo: International Advancement Center for Medicine & Health Research Co., Ltd., July 2013, Drug Discoveries & Therapeutics, Vol. 7, pp. 212-224. DOI: 10.5582/ddt.2013.v7.6.212; http://www.ddtjournal.com/getabstract.php?id=743. ISSN: 1881-7831.
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  26. Fight Psoriasis Naturally Through Ayurveda. Vibhooti, Papola, et al., et al. [ed.] Akash Dhokne. 7, North Shore City: Indo-American Pharmaceutical Society, 2016, Indo American Journal of Pharmaceutical Research, Vol. 6, pp. 6280-6290. ISSN: 2231-6876.
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  28. Flavonoids of the Flowers of Silybum marianum. Ahmed, Ahmed A., Mabry, Tom J. and Matlin, Stephen A. 6, s.l.: Elsevier Ltd., 1989, Phytochemistry, Vol. 28, pp. 1751-1753. ISSN: 0031-9422.
  29. Phenolic profile and in vitro antioxidant power of different milk thistle [Silybum marianum (L.) Gaertn.] cultivars. Lucini, Luigi, et al., et al. [ed.] M.J. Pascual-Villalobos, et al., et al. Murcia; St. Martin d'Hères; Fargo; Sao Paulo: Elsevier B.V., May 2016, Industrial Crops and Products, Vol. 83, pp. 11-16. DOI: 10.1016/j.indcrop.2015.12.023; http://www.sciencedirect.com/science/article/pii/S0926669015306129. ISSN: 0926-6690.
  30. Elemental analysis of some medicinal plants used in traditional medicine by atomic absorption spectrophotometer (AAS). Zafar, Muhammad, et al., et al. [ed.] Akah Peter Achunike. 19, Nsukka: Academic Journals, October 2010, Journal of Medicinal Plants Research, Vol. 4, pp. 1987-1990. DOI: 10.5897/JMPR10.081; http://academicjournals.org/journal/JMPR/article-abstract/644301915737. ISSN: 1996-0875.
  31. Properties of the seed oil of a dwarf cultivar of the pharmaceutical silymarin producing plant Silybum marianum (L.) Gaertn. developed in India. Bahi, J.R., et al., et al. [ed.] Sunita Garg. 2, New Delhi: National Institute of Science Communication And Information Resources, June 2015, Indian Journal of Natural Products and Resources, Vol. 6, pp. 127-133. ISSN: 0976-0512.
  32. Chymotrypsin Inhibitory Triterpenoids from Silybum marianum. Ahmed, Ejaz, et al., et al. [ed.] Yoshiji Takemoto. 1, Kyoto: International Academic Publishing Co., Ltd.: Phamnaceutical Society of Japan, January 2006, Chemical and Pharmaceutical Bulletin, Vol. 54, pp. 103-106. ISSN: 0009-2363.
  33. Detailed studies on some lipids of Silybum marianum(L.) seed oil. El-Mallah, M. Hassan, Safinaz, M. El-Shami and Hassanein, Minar M. [ed.] José María García Martos. 4, Seville: Consejo Superior de Investigaciones Científicas (CSIC), 2003, Grasas y Aceites: International Journal of Fats and Oils, Vol. 54, pp. 397-402. DOI: 10.3989/gya.2003.v54.i4.227; http://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/227/227. ISSN: 0017-3495.
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  35. Linkner, Edward (Lev) and Humphreys, Corene. Insulin Resistance and the Metabolic Syndrome. [ed.] David Rakel. Integrative Medicine. 3rd. Philadelphia: Saunders: Elsevier Inc., 2012, 31, pp. 284-296.e4. ISBN: 978-1-4377-1793-8.
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  37. Clinical Applications of Silybum marianum in Oncology. Greenlee, Heather, et al., et al. [ed.] Keith I. Block. 2, Chicago: Sage Publications, June 1, 2007, Integrative Cancer Therapies, Vol. 6, pp. 158-165. DOI: 10.1177/1534735407301727; http://journals.sagepub.com/doi/abs/10.1177/1534735407301727. ISSN: 1534-7354.
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  39. Galland, Leo. Inflammatory Bowel Disease. [ed.] David Rakel. Integrative Medicine. 3rd. Philadelphia: Saunders: Elsevier Inc., 2012, 49, pp. 464-474.e5. ISBN: 978-1-4377-1793-8.
  40. Gladstar, Rosemary. Rosemary Gladstar's Herbal Recipes for Vibrant Health: 175 Teas, Tonics, Oils, Salves, Tinctures, and Other Natural Remedies for the Entire Family. Adams: Storey Publishing, 2008. ISBN: 978-1-60342-078-5.
  41. Swallowtail Garden Seeds. Milk Thistle Seeds. Swallowtil Garden Seeds. [Online] 1998-2017. [Cited: February 26, 2017.] https://www.swallowtailgardenseeds.com/herbs/thistle_milk.html.
  42. On the pollen harvest by the honey bee (Apis mellifera L.) near Tucson, Arizona (1976-1981). O'Neal, Robert J. and Waller, Gordon D. 2, Tucson: University of Arizona; Boyce Thompson Arboretum, 1984, Desert Plants Journal, Vol. 6, pp. 81-109. DOI: 10150/552253; http://arizona.openrepository.com/arizona/handle/10150/552253. ISSN: 0734-3434.
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  44. Cheek, Linda S. Herb Survival Manual for North America. 2013.
  45. Ehrlich, Steven D. Milk thistle. University of Maryland Medical Center Medical Reference Guide: Complementary and Alternative Medicine Guide. [Online] May 26, 2014. [Cited: February 20, 2017.] http://umm.edu/health/medical/altmed/herb/milk-thistle.
  46. Silychristin, a Flavonolignan Derived From the Milk Thistle, Is a Potent Inhibitor of the Thyroid Hormone Transporter MCT8. Johannes, Jörg, et al., et al. [ed.] Andrea C. Gore and Stephen R. Hammes. 4, Austin; Rochester: The Endocrine Society, February 24, 2016, Endocrinology, Vol. 157, pp. 1694-1701. DOI: 10.1210/en.2015-1933; DOI: 10.1210/en.2015-1933; https://academic.oup.com/endo/article/157/4/1694/2422745. ISSN: 0013-7227.
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  48. In Vitro Antimicrobial and Modulatory Activity of the Natural Products Silymarin and Silibinin. de Oliveira, Dayanne Rakelly, et al., et al. [ed.] Glen Jickling. Article ID 292797, Davis: Hindawi Publishing Corporation, February 15, 2015, BioMed Research International, Vol. 2015, pp. 1-7. DOI: 10.1155/2015/292797; https://www.hindawi.com/journals/bmri/2015/292797/. ISSN: 1110-7243.
  49. Clinical efficacy, safety and tolerability of BIO-C® (micronized Silymarin) as a galactagogue. Pierro, Francesco Di, et al., et al. [ed.] Maurizio Vanelli. 3, Parma: Society of Medicine and Natural Sciences of Parma, December 2008, Acta BioMedica, Vol. 79, pp. 205-210. PMID: 19260380. ISSN: 0392-4203.
  50. Silibinin modulates the NF-κb pathway and pro-inflammatory cytokine production by mononuclear cells from preeclamptic women. Giorgi, Vanessa S. Innocenti, et al., et al. [ed.] Sarah A. Robertson, Shigeru Saito and D. Ware Branch. 1-2, Adelaide; Toyama; Salt Lake City: Elsevier Ireland Ltd., September 2012, Journal of Reproductive Immunology, Vol. 95, pp. 67-72. DOI: 10.1016/j.jri.2012.06.004; http://www.jrijournal.org/article/S0165-0378(12)00588-8/abstract. ISSN: 0165-0378.
  51. The impact of Silymarin on improvement of platelet abnormalities in patients with severe preeclampsia. Baghbahadorani, Fahimeh Kaveh and Miraj, Sepideh. [ed.] Mehrdad Jalalian and Parichehr Hanachi. 5, Kuala Lumpur; Tehran: Mehr Publishing, May 2016, Electronic Physician Journal, Vol. 8, pp. 2436-2442. DOI: 10.19082/2436; http://www.ephysician.ir/index.php/browse-issues/2016/5/388-2436. ISSN: 2008-5842.
  52. Solid-State Fermentation of Silybum marianum L. Seeds Used as Additive to Increase the Nutritional Value of Wheat Bread. Juodeikiene, Grazina, et al., et al. [ed.] Vladimir Mrša. 4, Zagreb: Faculty of Food Technology and Biotechnology, University of Zagreb, March 29, 2013, Food Technology and Biotechnology, Vol. 51, pp. 528-538. ISSN: 1330-9862.
  53. Linking diet to acne metabolomics, inflammation, and comedogenesis: an update. Melnik, Bodo C. [ed.] Jeffrey M. Weinberg. 8, New York City: Dove Press Ltd, July 15, 2015, Clinical, Cosmetic and Investigational Dermatology, Vol. 2015, pp. 371-388. DOI: 10.2147/CCID.S69135; https://www.dovepress.com/linking-diet-to-acne-metabolomics-inflammation-and-co. ISSN: 1178-7015.
  54. Protective effect of silymarin in antigen challenge- and histamine-induced bronchoconstriction in in vivo guinea-pigs. Breschi, M. Cristina, et al., et al. [ed.] F.P. Nijkamp. 1-2, Utrecht: Elsevier B.V., February 15, 2002, European Journal of Pharmacology, Vol. 437, pp. 91-95. DOI: 10.1016/S0014-2999(02)01265-7; http://www.sciencedirect.com/science/article/pii/S0014299902012657. ISSN: 0014-2999.
  55. Silymarin potentiates the anti-inflammatory effects of Celecoxib on chemically induced osteoarthritis in rats. Ashkavand, Z., et al., et al. [ed.] Hildebert Wagner. 13, München: Elsevier GmbH: Urban and Fischer, October 15, 2012, Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, Vol. 19, pp. 1200-1205. DOI: 10.1016/j.phymed.2012.07.008; http://www.sciencedirect.com/science/article/pii/S0944711312002395. ISSN: 0944-7113.
  56. Formulation and clinical evaluation of silymarin pluronic-lecithin organogels for treatment of atopic dermatitis. Mady, Fatma M., et al., et al. [ed.] Frank Boeckler and Jim Janetka. Tuebingen; St. Louis: Dove Press Ltd, March 10, 2016, Drug Design, Development and Therapy , Vol. 10, pp. 1101-1110. DOI: 10.2147/DDDT.S103423; https://www.dovepress.com/formulation-and-clinical-evaluation-of-silymarin-pluronic-lecithin-org-peer-reviewed-article-DDDT. ISSN: 1177-8881.
  57. In vitro effects on biofilm viability and antibacterial and antiadherent activities of silymarin. Evren, Ebru and Yurtcu, Erkan. [ed.] J. Mateju. 4, Prague: Springer International Publishing AGl Institute of Microbiology, Academy of Sciences of the Czech Republic and Czechoslavak Society for Microbiology, July 2015, Folia Microbiologica, Vol. 60, pp. 351-356. DOI: 10.1007/s12223-015-0399-6; http://link.springer.com/article/10.1007%2Fs12223-015-0399-6. ISSN: 0015-5632.
  58. The natural flavonoid silybin improves the response to Photodynamic Therapy of bladder cancer cells. Gándara, L., et al., et al. [ed.] László Mátyus and Robert Carpentier. Debrecen; Trois-Rivières: Elsevier B.V., April 5, 2014, Journal of Photochemistry and Photobiology B: Biology, Vol. 135, pp. 55-64. DOI: 10.1016/j.jphotobiol.2014.03.006; http://www.sciencedirect.com/science/article/pii/S1011134414000797. ISSN: 1011-1344.
  59. Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment. Lu, Ping, et al., et al. [ed.] Joe P. Huston. 2, Düsseldorf: Elsevier B.V., March 5, 2010, Behavioural Brain Research, Vol. 207, pp. 387-393. DOI: 10.1016/j.bbr.2009.10.024; http://www.sciencedirect.com/science/article/pii/S0166432809006329. ISSN: 0166-4328.
  60. Silibinin and Paclitaxel Cotreatment Significantly Suppress the Activity and Lung Metastasis of Triple Negative 4T1 Mammary Tumor Cell in Mice. Ho, Bing-Ying, et al., et al. [ed.] Lee-Yan Sheen. 4, Taipei: Elsevier, B.V., October-December 2012, Journal of Traditional and Complementary Medicine, Vol. 2, pp. 301-311. DOI: 10.1016/S2225-4110(16)30116-X; http://www.sciencedirect.com/science/article/pii/S222541101630116X. ISSN: 2225-4110.
  61. The effect of herbal medicine Silybum marianum (L.) Gaertn. seed extract on galactose induced cataract formation in rat. Huseini, Hasan Fallah, et al., et al. [ed.] Sh. Akhoundzadeh. 12, Tehran: Iranian Academic Center of Education, Culture and Research, December 2004, Journal of Medicinal Plants, Vol. 4, pp. 58-62. ISSN: 1684-0240.
  62. Synergistic Antibacterial Effect between Silibinin and Antibiotics in Oral Bacteria. Lee, Young-Soo, Jang, Kyeung-Ae and Cha, Jeong-Dan. [ed.] Ikhlas A. Khan. Article ID 618081, University: Hindawi Publishing Corporation, July 14, 2012, Journal of Biomedicine and Biotechnology, Vol. 2012, pp. 1-7. DOI: 10.1155/2012/618081; https://www.hindawi.com/journals/bmri/2012/618081/. ISSN: 1110-7243.
  63. Antiviral activity of silymarin against chikungunya virus. Lani, Rafidah, et al., et al. [ed.] Philip Campbell. Article number: 11421, London: Macmillan Publishers Limited, part of Springer Nature, June 16, 2015, Scientific Reports, Vol. 5. DOI: 10.1038/srep11421; http://www.nature.com/articles/srep11421. ISSN: 2045-2322.
  64. Topical application of silymarin reduces chemical-induced irritant contact dermatitis in BALB/c mice. Han, Mi Hwa, et al., et al. [ed.] J.E. Talmadge. 13, Omaha: Elsevier B.V., December 15, 2007, International Immunopharmacology, Vol. 7, pp. 1651-1658. DOI: 10.1016/j.intimp.2007.08.019; http://www.sciencedirect.com/science/article/pii/S1567576907002627. ISSN: 1567-5769.
  65. Potential antidepressant-like activity of silymarin in the acute restraint stress in mice: Modulation of corticosterone and oxidative stress response in cerebral cortex and hippocampus. Thakare, Vishnu N., Dhakane, Valmik D. and Patel, Bhoomika M. [ed.] Władysław Lason. 5, Kraków: Elsevier B.V., October 2016, Pharmacological Reports, Vol. 68, pp. 1020-1027. DOI: 10.1016/j.pharep.2016.06.002; http://www.sciencedirect.com/science/article/pii/S173411401630055X. ISSN: 1734-1140.
  66. Long-term (23 months) treatment with an anti-oxidant drug (silymarin) is effective on hyperinsulinemia, exogenous insulin need and malondialdehyde levels in cirrhotic diabetic patients. Velussi, Mario, et al., et al. [ed.] Gustav Paumgartner. 4, Munich: Elsevier Inc.: European Association for the Study of the Liver, April 1997, Journal of Hepatology, Vol. 26, pp. 871-879. DOI: 10.1016/S0168-8278(97)80255-3; http://www.journal-of-hepatology.eu/article/S0168-8278(97)80255-3/abstract. ISSN: 0168-8278.
  67. Effect of silymarin on kidneys of rats suffering from alloxan-induced diabetes mellitus. Soto, C., et al., et al. [ed.] Hildebert Wagner. 14, München: Elsevier GmbH: Urban and Fischer, December 1, 2010, Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, Vol. 17, pp. 1090-1094. DOI: 10.1016/j.phymed.2010.04.011; http://www.sciencedirect.com/science/article/pii/S0944711310001443. ISSN: 0944-7113.
  68. Effect of Addition of Silymarin to Renin-Angiotensin System Inhibitors on Proteinuria in Type 2 Diabetic Patients With Overt Nephropathy: A Randomized, Double-Blind, Placebo-Controlled Trial. Fallahzadeh, Mohammad Kazem, et al., et al. [ed.] Andrew S. Levey. 6, Philadelphia: Elsevier B.V., December 2012, American Journal of Kidney Diseases, Vol. 60, pp. 896-903. DOI: 10.1053/j.ajkd.2012.06.005; http://www.ajkd.org/article/S0272-6386(12)00860-8/abstract. ISSN: 0272-6386.
  69. Chronic treatment of silymarin improves hyperalgesia and motor nerve conduction velocity in diabetic neuropathic rat. Baluchnejadmojarad, Tourandokht, Roghani, Mehrdad and Khastehkhodaie, Zeynab. [ed.] Elizabeth M. Williamson, et al., et al. 8, Reading; Naples; Seoul; Charleston: John Wiley & Sons, Ltd., August 2010, Phytotherapy Research, Vol. 24, pp. 1120-1125. DOI: 10.1002/ptr.3078; http://onlinelibrary.wiley.com/doi/10.1002/ptr.3078/abstract. eISSN: 1099-1573.
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